今年初,中国科学家研发出了雾化吸入式的疫苗,不用打针,仅靠呼吸就能免疫新冠病毒。目前正在申请紧急授权。
所谓雾化吸入免疫,即采用雾化器将疫苗雾化成微小颗粒,通过呼吸吸入的方式进入呼吸道和肺部,从而激发黏膜免疫,而这种免疫是通过肌肉注射所不能带来的。通常,通过肌肉注射的新冠疫苗只能诱导体液免疫和细胞免疫。此外,使用雾化吸入方式免疫是无痛的,且拥有更高的可及性。
与此同时,加拿大科学家也在研究可口服的新冠疫苗!这对于哪些怕打针的小朋友真是个大喜讯。
研究发现,当把呼吸测试条放置在脸颊内侧或舌下时,这种呼吸测试条能有效地将蛋白质输送到血液中,引起免疫反应!
研究人员发现,QuickStrip™内的蛋白质在40°C下保持稳定。
对比一下现有的新冠疫苗,都需要冷藏和解冻,运输过程和储存都十分麻烦,消耗人力物力还容易过期。
如果有了新的口福疫苗,不但可以让人们自己带回家服用,说不定还可以在普通药店发售,今后新冠口服疫苗就和普通感冒药一样常见。
更让业内人士兴奋的是,这项技术不但可以改变新冠疫苗的播种方式,还可以改变其他病毒的疫苗播种方式。
如果这项口福技术应用在其他病毒上,那今后在许多情况下,人们都不必专门去某个地点打针了!
另一方面,这也可以有效提高全球疫苗的交付效率并且降低运输成本。
Rapid Dose Therapeutics公司高级副总裁Jason Lewis说:"世界上绝大多数国家都在努力获取和分发针剂疗法,我们正在实验的技术可以改善这一点。”
新技术可以解决很多问题:QuickStrip™不需要冷链储存或训练有素的专业人员给人打针,更不需要高昂的称嫩,还不需要担心针头的卫生问题。
Rapid Dose Therapeutics公司和McMaster大学于2020年7月开始研究这个技术,并在上个月结束了第一阶段的研究。
第二阶段将使用真正的新冠尖峰蛋白,这些资源由加拿大国家研究委员会提供。
研究人员将给QuickStrips™注入尖峰蛋白,希望这种疫苗能对新冠病毒产生免疫反应。
Rapid Dose Therapeutics公司首席执行官Mark Upsdell说,预计在几个月内会有初步结果,届时公司将开始商业化进程。
该项目的首席免疫学家Mark Larché博士表示,临床前结果和数据都表明QuickStrip™有能力提供治疗药物。
更进一步,这项新疫苗还有很大几率抵御变种病毒!
希望这个项目能进展顺利,这样我们今后都不用打针啦!

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